Conformational Properties, Interactions with Proteins, and Expansion of DNA Molecules Containing Tandem Repeats of the Triads Starting with Cytosine and Ending with Guanine

Authors

  • J. Kypr Biophysical Institute, Academy of Sciences of the Czech Republic, Brno
  • M. Vorlickova Biophysical Institute, Academy of Sciences of the Czech Republic, Brno

Abstract

The review concerns conformational properties, interactions with proteins, and expansion during replication of various DNA molecules containing simple sequence repeats (CAG)n, (CTG)n, (CCG)n, and (CGG)n. Attention is paid not only to the formed relatively stable intrastrand hairpins, but also to their associations into bimolecular heteroduplexes of the complementary strands which appear to have unusually compact conformations difficult to overcome during replication. It is pointed out that some simple sequence-repeat oligonucleotides are expanded by DNA polymerases even in the absence of any natural DNA. The review indicates that DNA conformations of the simple sequence repeats should be taken into account in the studies of genome function, evolution, and pathogenesis.

Published

1997-09-15

How to Cite

Kypr, J., & Vorlickova, M. (1997). Conformational Properties, Interactions with Proteins, and Expansion of DNA Molecules Containing Tandem Repeats of the Triads Starting with Cytosine and Ending with Guanine. Chemické Listy, 91(8). Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2753

Issue

Section

Articles